Protein Details: Aquaporin-4
Protein ID
ICDB_Pro_0620
Protein Name
Aquaporin-4
Gene Name
AQP4
Organism
Homo sapiens (Human)
Length
323 amino acids
AlphaFoldDB
AF-P55087-F1-model_v4.pdb
Function
Forms a water-specific channel. Plays an important role in brain water homeostasis . It is involved in glymphatic solute transport and is required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries;and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby;it is required for normal clearance of solutes from the brain interstitial fluid;including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability (By similarity).
Sequence
PDB Structures
Ligand Binding
Binding Site
Disease
Megalencephalic Leukoencephalopathy With Subcortical Cysts;Remitting and Brain Edema
Location
Detected in skeletal muscle (PubMed:29055082). Detected in stomach;along the glandular base region of the fundic gland (at protein level) (PubMed:8601457). Detected in brain;lung and skeletal muscle;and at much lower levels in heart and ovary (PubMed:7559426;PubMed:8601457). Detected in brain;lung and skeletal muscle;and at much lower levels in heart and ovary (PubMed:7559426;PubMed:8601457). Detected in brain;lung and skeletal muscle;and at much lower levels in heart and ovary (PubMed:7559426;PubMed:8601457).
DOI ID
10.1074/jbc.270.39.22907; 10.1016/0014-5793(96)00092-0; 10.1073/pnas.93.20.10908; 10.1038/nature03983; 10.1101/gr.2596504; 10.1093/hmg/dds032; 10.1111/jcmm.13401; 10.1073/pnas.0902725106; 10.1093/braiwad146
RefSeq
NP_001641.1 [P55087-1]; NP_004019.1 [P55087-2]